​赵丽华*

赵丽华，正高级职称，北京大学现代农业研究院PI，玛丽居里学者、泰山学者青年专家。主要研究领域为以拟南芥和大豆为模式植物，研究极端气候环境对植物生殖发育影响的分子机制。高温下大豆生殖发育关键调控基因的鉴定与功能解析。利用细胞生物学、分子生物学、遗传学和其他技术的整合，来阐明在不同的生物和非生物胁迫背景下控制雌配子体形成和分化的遗传途径，为开发高产和抗逆新作物品种提供理论依据。此外，还致力于改进whole mount-smFISH技术及其在植物生物学研究中的应用。

招生专业：

0951农业

研究方向：

高温下大豆生殖发育关键调控基因的鉴定与功能解析

联系方式：

lihua.zhao@pku-iaas.edu.cn

学术成果：

[1]hao, L. ^#, A. Fonseca^#, A. Meschichi, A. Sicard & S. Rosa (2023) Whole-mount smFISH allows combining RNA and protein quantification at cellular and subcellular resolution. Nat Plants.

[2]Zhao, L. ^#, L. Liu, Y. Liu, X. Dou, H. Cai, M. Aslam, Z. Hou, X. Jin, Y. Li, L. Wang, H. Zhao, X. Wang, A. Sicard & Y. Qin (2021) Characterization of germline development and identification of genes associated with germline specification in pineapple. Hortic Res, 8, 239.

[3] Lihua Zhao^#, Hanyang Cai^#, Zhenxia Su^#, Lulu Wang, Xinyu Huang, Man Zhang, Piaojuan Chen,Xiaozhuan Dai, Heming Zhao, Ravishankar Palanivelu, Xuemei Chen and Yuan Qin.(2017)KLU suppresses megasporocyte cell fate through SWR1-mediated activation ofWRKY28 expression in Arabidopsis. PNAS. 115 (3) E526-E535.

[4] Dai X^#, Bai Y^#, Zhao L^#, Dou X^#, Liu Y, Wang L, Li Y, Li W, Hui Y, Huang X, Wang Z*, Qin Y*. (2017) H2A.Zrepresses gene expression by modulating promoter nucleosome structure and enhancer histone modifications in Arabidopsis. Molecular Plant.

[5] Zhenxia Su^#, Lihua Zhao^#, Yuanyuan Zhao, Shaofang Li, SoYoun Won, Hanyang Cai, Lulu Wang, Zhenfang Li, Piaojuan Chen, Yuan Qin^*, Xuemei Chen^*（2017）The THO Complex Non-Cell-Autonomously Represses Female Germline Specification through the TAS3-ARF3 Module.Current Biology.27（11）：1597-1609.

[6] Cai H^#, Zhao L^#, Wang L, Zhang M, Su Z, Cheng Y, Zhao H, Qin Y*. (2017) ERECTA signaling controls Arabidopsis inflorescence architecture through chromatin-mediated activation of PRE1 expression. New Phytologist. DOI: 10.1111/nph.14521.

[7] Lihua Zhao, Jiangman He, Hanyang Cai, Haiyan Lin, Renyi Liu, Zhenbiao Yang, Yuan Qin. (2014)Comparative expression profiling reveals novel gene functions in female meiosis and gametophyte development in Arabidopsis. Plant Journal. 80(4):615-28.

[8] Meschichi A, Zhao L, Reeck S, White C, Da Ines O, Sicard A, Pontvianne F, Rosa S*. 2022. The plant-specific DDR factor SOG1 increases chromatin mobility in response to DNA damage. EMBO Rep, 23(12):e54736.

[9] Antoniou-Kourounioti R L, Meschichi A, Reeck S, Berry S, Menon G, Zhao Y, Fozard J, Holmes T, Zhao L, Wang H, Hartley M, Dean C, Rosa S*, Howard M*. 2023. Integrating analog and digital modes of gene expression at Arabidopsis FLC. Elife, 12.

[10] Hou Z, Liu Y, Zhang M, Zhao L, Jin X, Liu L, Su Z, Cai H, Qin Y*. 2021. High-throughput single-cell transcriptomics reveals the female germline differentiation trajectory in Arabidopsis thaliana. Commun Biol, 4(1):1149.

[11] Zhang X, Wang G, Zhang S, Chen S, Wang Y, Wen P, Ma X, Shi Y, Qi R, Yang Y, Liao Z, Lin J, Lin J, Xu X, Chen X, Xu X, Deng F, Zhao L, Lee Y L, Wang R, Chen X Y, Lin Y R, Zhang J, Tang H, Chen J, Ming R*. 2020. Genomes of the Banyan Tree and Pollinator Wasp Provide Insights into Fig-Wasp Coevolution. Cell, 183(4):875-889 e817.

[12] Liu L, Zhao L, Chen P, Cai H, Hou Z, Jin X, Aslam M, Chai M, Lai L, He Q, Liu Y, Huang X, Chen H, Chen Y, Qin Y*. 2020. ATP binding cassette transporters ABCG1 and ABCG16 affect reproductive development via auxin signalling in Arabidopsis. Plant J, 102(6):1172-1186.

[13] Wang L, Li Y, Jin X, Liu L, Dai X, Liu Y, Zhao L, Zheng P, Wang X, Liu Y, Lin D, Qin Y*. 2020. Floral transcriptomes reveal gene networks in pineapple floral growth and fruit development. Commun Biol, 3(1):500.

[14] Cai H, Zhang M, Chai M, He Q, Huang X, Zhao L, Qin Y*. 2019. Epigenetic regulation of anthocyanin biosynthesis by an antagonistic interaction between H2A.Z and H3K4me3. New Phytol, 221(1):295-308.

[15] Cao L, Wang S, Venglat P, Zhao L, Cheng Y, Ye S, Qin Y, Datla R, Zhou Y, Wang H*. 2018. Arabidopsis ICK/KRP cyclin-dependent kinase inhibitors function to ensure the formation of one megaspore mother cell and one functional megaspore per ovule. PLoS Genet, 14(3):e1007230.

科研项目及获奖：

1.科研项目：

[1] 2022.01 – 2023.1：瑞典研究理事会项目：Unravelling the mechanism underlying temperature-induced germline determination failure in plants（2023-04409），结题。赵丽华/1。

[2] 2022.01 – 2023.12：欧盟“玛丽.居里学者人才计划”项目：Evolution of organ size scaling in plants (MSCA-IF 101032710)，已结题，赵丽华/1。

[3] 2017.01-2019.12：国家自然科学基金青年项目：KLU调控下游转录因子WRKY23影响拟南芥胚顶基轴模式建成的研究 (31600249)，已结题，赵丽华/1。

[4] 2017.06-202.06：福建省自然科学基金面上项目：菠萝配子发育及转录组分析研究(2017J01601)，已结题，赵丽华/1。

[5] 2016.01-2018.12：福建农林大学校优博基金项目：KLU通过SWR1激活AKD2表达来抑制拟南芥大孢子母细胞发生过程，已结题，赵丽华/1。

[6] 2024.01-2026.12：山东省优秀青年科学基金项目：植物生殖细胞特化的温度适应机制（2024HWYQ-88），在研，赵丽华/1。

[7] 2024-11-2026.12：山东省泰山学者青年专家：高温对植物大孢子母细胞形成的影响及其分子机制(tsqn202312308), 在研，赵丽华/1。

2. 获奖：

[1] 2019年获福建省优秀博士论文奖，赵丽华/1。